Saint Louis is served by a number of major highways. Among these are Interstates 64, 70, 55, and 270. Also within the the area are parts of Historic Routes 66, 67, 40, and others. The Renaissance St. Louis Hotel is located at 9801 Natural Bridge Road.
Lambert International Airport is located literally across the I-70 intrstate from the show venue.
Here are a couple maps to help you get oriented when visiting the Saint Louis Stamp Expo.